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Approximate posterior estimation for GLM coefficients

Bioconductor version: Release (3.19)

apeglm provides Bayesian shrinkage estimators for effect sizes for a variety of GLM models, using approximation of the posterior for individual coefficients.

Author: Anqi Zhu [aut, cre], Joshua Zitovsky [ctb], Joseph Ibrahim [aut], Michael Love [aut]

Maintainer: Anqi Zhu <anqizhu at>

Citation (from within R, enter citation("apeglm")):


To install this package, start R (version "4.4") and enter:

if (!require("BiocManager", quietly = TRUE))


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:

Effect size estimation with apeglm HTML R Script
Reference Manual PDF


biocViews Bayesian, DifferentialExpression, GeneExpression, ImmunoOncology, RNASeq, Sequencing, Software
Version 1.26.1
In Bioconductor since BioC 3.6 (R-3.4) (6.5 years)
License GPL-2
Imports emdbook, SummarizedExperiment, GenomicRanges, methods, stats, utils, Rcpp
System Requirements
See More
Suggests DESeq2, airway, knitr, rmarkdown, testthat
Linking To Rcpp, RcppEigen, RcppNumerical
Depends On Me rnaseqGene
Imports Me airpart, debrowser, DiffBind, ERSSA, Rmmquant, TEKRABber
Suggests Me bambu, dar, DESeq2, fishpond, NanoporeRNASeq, RNAseqQC
Links To Me
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Package Archives

Follow Installation instructions to use this package in your R session.

Source Package apeglm_1.26.1.tar.gz
Windows Binary (64-bit only)
macOS Binary (x86_64) apeglm_1.26.1.tgz
macOS Binary (arm64) apeglm_1.26.1.tgz
Source Repository git clone
Source Repository (Developer Access) git clone
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Old Source Packages for BioC 3.19 Source Archive