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Dispersion shrinkage for sequencing data

Bioconductor version: Release (3.19)

DSS is an R library performing differntial analysis for count-based sequencing data. It detectes differentially expressed genes (DEGs) from RNA-seq, and differentially methylated loci or regions (DML/DMRs) from bisulfite sequencing (BS-seq). The core of DSS is a new dispersion shrinkage method for estimating the dispersion parameter from Gamma-Poisson or Beta-Binomial distributions.

Author: Hao Wu<hao.wu at>, Hao Feng<hxf155 at>

Maintainer: Hao Wu <hao.wu at>, Hao Feng <hxf155 at>

Citation (from within R, enter citation("DSS")):


To install this package, start R (version "4.4") and enter:

if (!require("BiocManager", quietly = TRUE))


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:

The DSS User's Guide HTML R Script
Reference Manual PDF


biocViews DNAMethylation, DifferentialExpression, DifferentialMethylation, GeneExpression, RNASeq, Sequencing, Software
Version 2.52.0
In Bioconductor since BioC 2.11 (R-2.15) (12 years)
License GPL
Depends R (>= 3.5.0), methods, Biobase, BiocParallel, bsseq, parallel
Imports utils, graphics, stats, splines
System Requirements
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Suggests BiocStyle, knitr, rmarkdown, edgeR
Linking To
Depends On Me DeMixT
Imports Me borealis, kissDE, metaseqR2, methylSig
Suggests Me biscuiteer, methrix, NanoMethViz
Links To Me
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Package Archives

Follow Installation instructions to use this package in your R session.

Source Package DSS_2.52.0.tar.gz
Windows Binary
macOS Binary (x86_64) DSS_2.52.0.tgz
macOS Binary (arm64) DSS_2.52.0.tgz
Source Repository git clone
Source Repository (Developer Access) git clone
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