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Cleavage of Polypeptide Sequences

Bioconductor version: Release (3.18)

In-silico cleavage of polypeptide sequences. The cleavage rules are taken from: http://web.expasy.org/peptide_cutter/peptidecutter_enzymes.html

Author: Sebastian Gibb [aut, cre]

Maintainer: Sebastian Gibb <mail at sebastiangibb.de>

Citation (from within R, enter citation("cleaver")):


To install this package, start R (version "4.3") and enter:

if (!require("BiocManager", quietly = TRUE))


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:

In-silico cleavage of polypeptides HTML R Script
Reference Manual PDF


biocViews Proteomics, Software
Version 1.40.0
In Bioconductor since BioC 2.13 (R-3.0) (10.5 years)
License GPL (>= 3)
Depends R (>= 3.0.0), methods, Biostrings(>= 1.29.8)
Imports S4Vectors, IRanges
System Requirements
URL https://github.com/sgibb/cleaver/
Bug Reports https://github.com/sgibb/cleaver/issues/
See More
Suggests testthat (>= 0.8), knitr, BiocStyle(>= 0.0.14), rmarkdown, BRAIN, UniProt.ws(>= 2.36.5)
Linking To
Depends On Me
Imports Me ProteoDisco, synapter
Suggests Me RforProteomics
Links To Me
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Package Archives

Follow Installation instructions to use this package in your R session.

Source Package cleaver_1.40.0.tar.gz
Windows Binary cleaver_1.40.0.zip (64-bit only)
macOS Binary (x86_64) cleaver_1.40.0.tgz
macOS Binary (arm64) cleaver_1.40.0.tgz
Source Repository git clone https://git.bioconductor.org/packages/cleaver
Source Repository (Developer Access) git clone git@git.bioconductor.org:packages/cleaver
Bioc Package Browser https://code.bioconductor.org/browse/cleaver/
Package Short Url https://bioconductor.org/packages/cleaver/
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