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Tools for the analysis of heterogeneous tissues

Bioconductor version: Release (3.18)

This package is devoted to analyzing high-throughput data (e.g. gene expression microarray, DNA methylation microarray, RNA-seq) from complex tissues. Current functionalities include 1. detect cell-type specific or cross-cell type differential signals 2. tree-based differential analysis 3. improve variable selection in reference-free deconvolution 4. partial reference-free deconvolution with prior knowledge.

Author: Ziyi Li and Weiwei Zhang and Luxiao Chen and Hao Wu

Maintainer: Ziyi Li <zli16 at mdanderson.org>

Citation (from within R, enter citation("TOAST")):


To install this package, start R (version "4.3") and enter:

if (!require("BiocManager", quietly = TRUE))


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:

The TOAST User's Guide HTML R Script
Reference Manual PDF


biocViews DNAMethylation, DifferentialExpression, DifferentialMethylation, Epigenetics, GeneExpression, GeneTarget, MethylationArray, Microarray, Software
Version 1.16.0
In Bioconductor since BioC 3.10 (R-3.6) (4.5 years)
License GPL-2
Depends R (>= 3.6), EpiDISH, limma, nnls, quadprog
Imports stats, methods, SummarizedExperiment, corpcor, doParallel, parallel, ggplot2, tidyr, GGally
System Requirements
Bug Reports https://github.com/ziyili20/TOAST/issues
See More
Suggests BiocStyle, knitr, rmarkdown, gplots, matrixStats, Matrix
Linking To
Depends On Me
Imports Me MICSQTL, RegionalST
Suggests Me
Links To Me
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Package Archives

Follow Installation instructions to use this package in your R session.

Source Package TOAST_1.16.0.tar.gz
Windows Binary TOAST_1.16.0.zip
macOS Binary (x86_64) TOAST_1.16.0.tgz
macOS Binary (arm64) TOAST_1.16.0.tgz
Source Repository git clone https://git.bioconductor.org/packages/TOAST
Source Repository (Developer Access) git clone git@git.bioconductor.org:packages/TOAST
Bioc Package Browser https://code.bioconductor.org/browse/TOAST/
Package Short Url https://bioconductor.org/packages/TOAST/
Package Downloads Report Download Stats