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Open-source toolkit to analyse data from xCELLigence System (RTCA)

Bioconductor version: Release (3.19)

Import, analyze and visualize data from Roche(R) xCELLigence RTCA systems. The package imports real-time cell electrical impedance data into R. As an alternative to commercial software shipped along the system, the Bioconductor package RTCA provides several unique transformation (normalization) strategies and various visualization tools.

Author: Jitao David Zhang

Maintainer: Jitao David Zhang <davidvonpku at>

Citation (from within R, enter citation("RTCA")):


To install this package, start R (version "4.4") and enter:

if (!require("BiocManager", quietly = TRUE))


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:

Introduction to Data Analysis of the Roche xCELLigence System with RTCA Package PDF R Script
RTCAtransformation: Discussion of transformation methods of RTCA data PDF R Script
Reference Manual PDF


biocViews CellBasedAssays, ImmunoOncology, Infrastructure, Software, TimeCourse, Visualization
Version 1.56.0
In Bioconductor since BioC 2.5 (R-2.10) (14.5 years)
License LGPL-3
Depends methods, stats, graphics, Biobase, RColorBrewer, gtools
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Follow Installation instructions to use this package in your R session.

Source Package RTCA_1.56.0.tar.gz
Windows Binary
macOS Binary (x86_64) RTCA_1.56.0.tgz
macOS Binary (arm64) RTCA_1.56.0.tgz
Source Repository git clone
Source Repository (Developer Access) git clone
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