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Interactive Workflow for Discovering Rhythmicity in Biological Data

Bioconductor version: Release (3.19)

Set of functions for estimation of cyclical characteristics, such as period, phase, amplitude, and statistical significance in large temporal datasets. Supporting functions are available for quality control, dimensionality reduction, spectral analysis, and analysis of experimental replicates. Contains a R Shiny web interface to execute all workflow steps.

Author: Matthew Carlucci [aut, cre], Algimantas Kriščiūnas [aut], Haohan Li [aut], Povilas Gibas [aut], Karolis Koncevičius [aut], Art Petronis [aut], Gabriel Oh [aut]

Maintainer: Matthew Carlucci <Matthew.Carlucci at>

Citation (from within R, enter citation("DiscoRhythm")):


To install this package, start R (version "4.4") and enter:

if (!require("BiocManager", quietly = TRUE))


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:

Introduction to DiscoRhythm HTML R Script
Reference Manual PDF


biocViews GUI, PrincipalComponent, QualityControl, Software, TimeCourse, Visualization
Version 1.20.0
In Bioconductor since BioC 3.9 (R-3.6) (5 years)
License GPL-3
Depends R (>= 3.6.0)
Imports matrixTests, matrixStats, MetaCycle (>= 1.2.0), data.table, ggplot2, ggExtra, dplyr, broom, shiny, shinyBS, shinycssloaders, shinydashboard, shinyjs, BiocStyle, rmarkdown, knitr, kableExtra, magick, VennDiagram, UpSetR, heatmaply, viridis, plotly, DT, gridExtra, methods, stats, SummarizedExperiment, BiocGenerics, S4Vectors, zip, reshape2
System Requirements To generate html reports pandoc ( is required.
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Follow Installation instructions to use this package in your R session.

Source Package DiscoRhythm_1.20.0.tar.gz
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macOS Binary (x86_64) DiscoRhythm_1.20.0.tgz
macOS Binary (arm64) DiscoRhythm_1.20.0.tgz
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