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plaid

This is the released version of plaid; for the devel version, see plaid.

PLAID ultrafast gene set enrichment scoring


Bioconductor version: Release (3.23)

PLAID (Pathway Level Average Intensity Detection) is an ultra-fast method to compute single-sample enrichment scores for gene expression or proteomics data. For each sample, plaid computes the gene set score as the average intensity of the genes/proteins in the gene set. The output is a gene set score matrix suitable for further analyses.

Author: Ivo Kwee [aut] ORCID iD ORCID: 0000-0002-2751-4218 , Antonino Zito [cre] ORCID iD ORCID: 0000-0003-1931-984X

Maintainer: Antonino Zito <antonino.zito at bigomics.ch>

Citation (from within R, enter citation("plaid")):
Seminal Bioconductor project articles:

Huber W, Carey VJ, Gentleman R, Anders S, Carlson M, Carvalho BS, Bravo HC, Davis S, Gatto L, Girke T, Gottardo R, Hahne F, Hansen KD, Irizarry RA, Lawrence M, Love MI, MacDonald J, Obenchain V, Oleś AK, Pagès H, Reyes A, Shannon P, Smyth GK, Tenenbaum D, Waldron L, Morgan M (2015). "Orchestrating high-throughput genomic analysis with Bioconductor." Nature Methods, 12(2), 115–121. doi:10.1038/nmeth.3252.

Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, Ellis B, Gautier L, Ge Y, Gentry J, Hornik K, Hothorn T, Huber W, Iacus S, Irizarry R, Leisch F, Li C, Maechler M, Rossini AJ, Sawitzki G, Smith C, Smyth G, Tierney L, Yang JYH, Zhang J (2004). "Bioconductor: open software development for computational biology and bioinformatics." Genome Biology, 5(10), R80. doi:10.1186/gb-2004-5-10-r80.

Installation

To install this package, start R (version "4.6") and enter:


if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("plaid")

For older versions of R, please refer to the appropriate Bioconductor release.

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("plaid")
Comparing PLAID with other methods HTML R Script
Getting Started with PLAID HTML R Script
Reference Manual PDF
NEWS Text

Details

biocViews GeneExpression, GeneSetEnrichment, Proteomics, Software
Version 1.0.0
In Bioconductor since BioC 3.23 (R-4.6) (< 6 months)
License GPL-3
Depends R (>= 4.3.3)
Imports Matrix, MatrixGenerics, matrixStats, methods, parallel, Rfast, qlcMatrix, GSVA, fgsea, SummarizedExperiment, BiocSet, stats, utils
System Requirements
URL https://github.com/bigomics/plaid https://bigomics.github.io/plaid/
Bug Reports https://github.com/bigomics/plaid/issues
See More
Suggests BiocStyle, knitr, rmarkdown, sparseMatrixStats, testthat (>= 3.0.0)
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Package Archives

Follow Installation instructions to use this package in your R session.

Source Package plaid_1.0.0.tar.gz
Windows Binary (x86_64) plaid_1.0.0.zip
macOS Binary (big-sur-x86_64) plaid_1.0.0.tgz
macOS Binary (sonoma-arm64) plaid_1.0.0.tgz
Source Repository git clone https://git.bioconductor.org/packages/plaid
Source Repository (Developer Access) git clone git@git.bioconductor.org:packages/plaid
Bioc Package Browser https://code.bioconductor.org/browse/plaid/
Package Short Url https://bioconductor.org/packages/plaid/
Package Downloads Report Download Stats