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edgeR

This is the development version of edgeR; for the stable release version, see edgeR.

All versions 3.24 (devel), 3.23 (release), 3.22, 3.21, 3.20, 3.19, 3.18, 3.17, 3.16, 3.15, 3.14, 3.13, 3.12, 3.11, 3.10, 3.9, 3.8, 3.7, 3.6, 3.5, 3.4, 3.3, 3.2, 3.1, 3.0, 2.14, 2.13, 2.12, 2.11, 2.10, 2.9, 2.8, 2.7, 2.6, 2.5

Empirical Analysis of Digital Gene Expression Data in R


Bioconductor version: Development (3.24)

Differential expression analysis of sequence count data. Implements a range of statistical methodology based on the negative binomial distributions, including empirical Bayes estimation, exact tests, generalized linear models, quasi-likelihood, and gene set enrichment. Can perform differential analyses of any type of omics data that produces read counts, including RNA-seq, ChIP-seq, ATAC-seq, Bisulfite-seq, SAGE, CAGE, metabolomics, or proteomics spectral counts. RNA-seq analyses can be conducted at the gene or isoform level, and tests can be conducted for differential exon or transcript usage.

Author: Yunshun Chen, Lizhong Chen, Aaron TL Lun, Davis J McCarthy, Pedro Baldoni, Matthew E Ritchie, Belinda Phipson, Yifang Hu, Xiaobei Zhou, Mark D Robinson, Gordon K Smyth

Maintainer: Yunshun Chen <yuchen at wehi.edu.au>, Gordon Smyth <smyth at wehi.edu.au>

Citation (from within R, enter citation("edgeR")):

Yunshun Chen, Lizhong Chen, Aaron TL Lun, Davis J McCarthy, Pedro Baldoni, Matthew E Ritchie, Belinda Phipson, Yifang Hu, Xiaobei Zhou, Mark D Robinson, Gordon K Smyth. edgeR: Empirical Analysis of Digital Gene Expression Data in R. doi:10.18129/B9.bioc.edgeR, R package version 4.99.6, https://bioconductor.org/packages/edgeR.

Generated from the package metadata; it may differ from the package's own citation.

Installation

To install this package, start R (version "4.6") and enter:

if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

## The following initializes the development version of Bioconductor
BiocManager::install(version = "devel")

BiocManager::install("edgeR")

For older versions of R, please refer to the appropriate Bioconductor release.

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("edgeR")
edgeR User's Guide PDF
A brief introduction to edgeR HTML R Script
Reference ManualPDF
NEWSText

Details

biocViews AlternativeSplicing, BatchEffect, Bayesian, BiomedicalInformatics, CellBiology, ChIPSeq, Clustering, Coverage, DNAMethylation, DifferentialExpression, DifferentialMethylation, DifferentialSplicing, Epigenetics, FunctionalGenomics, GeneExpression, GeneSetEnrichment, Genetics, ImmunoOncology, MultipleComparison, Normalization, Pathways, Proteomics, QualityControl, RNASeq, Regression, SAGE, Sequencing, SingleCell, Software, SystemsBiology, TimeCourse, Transcription, Transcriptomics
Version4.99.6
In Bioconductor sinceBioC 2.3 (R-2.8) (18 years)
License GPL (>=2)
Depends R (>= 3.6.0), limma (>= 3.63.6)
Imports methods, graphics, stats, utils, locfit
System Requirements
URLhttps://bioinf.wehi.edu.au/edgeR/ https://bioconductor.org/packages/edgeR
See More
Suggests jsonlite, knitr, Matrix, nanoparquet, readr, rhdf5, SeuratObject, splines, AnnotationDbi, Biobase, BiocStyle, org.Hs.eg.db, S4Vectors, SummarizedExperiment
Linking To
Enhances
Depends On Me ASpli, babel, BALLI, BioInsight, EGSEA123, IntEREst, methylMnM, miloR, octad, ReactomeGSA.data, RNAseq123, rnaseqDTU, RnaSeqGeneEdgeRQL, RnaSeqSampleSizeData, RUVSeq, TCC, tRanslatome
Imports Me affycoretools, aIc, anota2seq, ATACseqQC, augere.de, augere.screen, autonomics, AWFisher, BatchQC, baySeq, beer, benchdamic, BioQC, BreastSubtypeR, broadSeq, censcyt, ChromSCape, cinaR, circRNAprofiler, CleanUpRNAseq, clusterExperiment, CNVRanger, compcodeR, CoreMicrobiomeR, coseq, countsimQC, cpam, csaw, cypress, DaMiRseq, Damsel, daVis, debrowser, DeeDeeExperiment, DEFormats, DEGreport, DESpace, DEsubs, diffcyt, diffHic, diffUTR, diffwrap, dinoR, DMRcate, doseR, dreamlet, DRIMSeq, DropletUtils, DspikeIn, easyRNASeq, EGSEA, eisaR, emtdata, EnrichmentBrowser, erccdashboard, ERSSA, ExpHunterSuite, extraChIPs, GDCRNATools, GenomicPlot, GExPipe, gg4way, gINTomics, Glimma, GSEABenchmarkeR, GSEAlens, hermes, hicream, HTSCluster, HTSFilter, icetea, idiffomix, infercnv, influential, iSEEde, IsoformSwitchAnalyzeR, KnowSeq, LIPIDIFy, Maaslin2, markeR, mastR, MEB, MEDIPS, MetaDICT, metaseqR2, microbial, MIRit, MLSeq, mobileRNA, MOSim, Motif2Site, msgbsR, msmsTests, multiHiCcompare, MultiOmicsBridge, muscat, mutscan, netZooR, pathdb, PathoStat, phantasus, PhIPData, ppcseq, PRONE, PROPER, psichomics, RCM, RCPA, recountWorkflow, regsplice, ReportingTools, RFLOMICS, RNAseqCovarImpute, RnaSeqSampleSize, ROSeq, Rvisdiff, saseR, scCB2, scde, scone, scran, ScreenR, SEtools, shinyDSP, SIMD, simPIC, singscore, SpaNorm, sparrow, spatialHeatmap, spatialLIBD, speckle, splatter, SPsimSeq, srnadiff, ssizeRNA, sSNAPPY, standR, STATegRa, Statial, SurfR, sva, SwarnSeq, TBSignatureProfiler, TCseq, tradeSeq, TransProR, treeclimbR, treekoR, TSGS, tweeDEseq, vidger, VISTA, xcore, XYomics, yarn, zinbwave
Suggests Me ABSSeq, augere.core, BenchHub, CAGEWorkflow, chipseqDB, ClassifyR, cqn, cydar, DAssemble, dcanr, dearseq, DEScan2, DGEobj, DGEobj.utils, DiffBind, DiPALM, dittoSeq, DSS, easybio, easyreporting, EDASeq, gage, gCrisprTools, GenomicAlignments, GenomicRanges, GeoTcgaData, ggpicrust2, glmGamPoi, glmmSeq, goseq, groHMM, GSAR, GSVA, ideal, inDAGO, iSEEpathways, iSEEu, leeBamViews, lemur, levi, MiscMetabar, missMethyl, MoonlightR, multiMiR, palasso, pctax, pmartR, raer, recount, regionReport, RFGeneRank, ribosomeProfilingQC, satuRn, scider, SeqGate, seqgendiff, seqwrap, SIBERG, signifinder, SpliceWiz, stageR, subSeq, systemPipeR, TCGAbiolinks, TFEA.ChIP, tidybulk, tidyexposomics, topconfects, transmogR, tximeta, tximport, variancePartition, volcano3D, weitrix, Wrench, zenith, zFPKM
Links To Me
Build Report Build Report, r-universe

Package Archives

Follow Installation instructions to use this package in your R session.

Source Package edgeR_4.99.6.tar.gz
Windows Binary (x86_64) edgeR_4.99.6.zip
macOS Binary (big-sur-x86_64) edgeR_4.99.6.tgz
macOS Binary (sonoma-arm64) edgeR_4.99.6.tgz
Source Repositorygit clone https://git.bioconductor.org/packages/edgeR
Source Repository (Developer Access)git clone git@git.bioconductor.org:packages/edgeR
Package Short Url https://bioconductor.org/packages/edgeR/
Package Downloads ReportDownload Stats