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ANCOMBC

This is the development version of ANCOMBC; for the stable release version, see ANCOMBC.

All versions 3.24 (devel), 3.23 (release), 3.22, 3.21, 3.20, 3.19, 3.18, 3.17, 3.16, 3.15, 3.14, 3.13, 3.12

Microbiome differential abudance and correlation analyses with bias correction


Bioconductor version: Development (3.24)

ANCOMBC is a package containing differential abundance (DA) and correlation analyses for microbiome data. Specifically, the package includes Analysis of Compositions of Microbiomes with Bias Correction 2 (ANCOM-BC2), Analysis of Compositions of Microbiomes with Bias Correction (ANCOM-BC), and Analysis of Composition of Microbiomes (ANCOM) for DA analysis, and Sparse Estimation of Correlations among Microbiomes (SECOM) for correlation analysis. Microbiome data are typically subject to two sources of biases: unequal sampling fractions (sample-specific biases) and differential sequencing efficiencies (taxon-specific biases). Methodologies included in the ANCOMBC package are designed to correct these biases and construct statistically consistent estimators.

Author: Huang Lin [cre, aut] ORCID iD ORCID: 0000-0002-4892-7871

Maintainer: Huang Lin <huanglinfrederick at gmail.com>

Citation (from within R, enter citation("ANCOMBC")):

Huang Lin. ANCOMBC: Microbiome differential abudance and correlation analyses with bias correction. doi:10.18129/B9.bioc.ANCOMBC, R package version 2.15.1, https://bioconductor.org/packages/ANCOMBC.

Generated from the package metadata; it may differ from the package's own citation.

Installation

To install this package, start R (version "4.6") and enter:

if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

## The following initializes the development version of Bioconductor
BiocManager::install(version = "devel")

BiocManager::install("ANCOMBC")

For older versions of R, please refer to the appropriate Bioconductor release.

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("ANCOMBC")
ANCOM Tutorial HTML R Script
ANCOM-BC Tutorial HTML R Script
ANCOM-BC2 Tutorial HTML R Script
Tutorial on Data Sanity and Integrity Checks HTML R Script
SECOM Tutorial HTML R Script
Reference ManualPDF
NEWSText

Details

biocViews DifferentialExpression, Microbiome, Normalization, Sequencing, Software
Version2.15.1
In Bioconductor sinceBioC 3.12 (R-4.0) (6 years)
License Artistic-2.0
Depends R (>= 4.5.0)
Imports stats, DescTools, Hmisc, MASS, Matrix, Rdpack, doParallel, doRNG, energy, foreach, gtools, lme4, lmerTest, multcomp, nloptr, parallel, utils, quadprog
System Requirements
URLhttps://github.com/FrederickHuangLin/ANCOMBC
Bug Reportshttps://github.com/FrederickHuangLin/ANCOMBC/issues
See More
Suggests mia (>= 1.18.0), DT, S4Vectors, SingleCellExperiment, SummarizedExperiment, TreeSummarizedExperiment, dplyr, knitr, magrittr, microbiome, phyloseq, rmarkdown, testthat, tidyr, tidyverse
Linking To
Enhances
Depends On Me
Imports Me benchdamic
Suggests Me dar, DAssemble, MiscMetabar
Links To Me
Build Report Build Report, r-universe

Package Archives

Follow Installation instructions to use this package in your R session.

Source Package ANCOMBC_2.15.1.tar.gz
Windows Binary (x86_64) ANCOMBC_2.15.1.zip
macOS Binary (big-sur-x86_64) ANCOMBC_2.15.1.tgz
macOS Binary (sonoma-arm64) ANCOMBC_2.15.1.tgz
Source Repositorygit clone https://git.bioconductor.org/packages/ANCOMBC
Source Repository (Developer Access)git clone git@git.bioconductor.org:packages/ANCOMBC
Package Short Url https://bioconductor.org/packages/ANCOMBC/
Package Downloads ReportDownload Stats