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cellNexus

This is the development version of cellNexus; to use it, please install the devel version of Bioconductor.

Queries the Human Cell Atlas


Bioconductor version: Development (3.24)

Provides access to a copy of the Human Cell Atlas, but with harmonised metadata. This allows for uniform querying across numerous datasets within the Atlas using common fields such as cell type, tissue type, and patient ethnicity. Usage involves first querying the metadata table for cells of interest, and then downloading the corresponding cells into one of several supported formats, including SingleCellExperiment, Seurat, or pseudobulk SummarizedExperiment objects. Note: The Human Cell Atlas data accessed through this package is subject to its own licensing terms (typically Creative Commons Attribution or similar open data licenses as specified by the Human Cell Atlas Data Use Agreement), which differ from the package license (GPL-3). See the package documentation for details.

Author: Stefano Mangiola [aut, rev, ctb] ORCID iD ORCID: 0000-0001-7474-836X , Mengyuan Shen [aut, cre, rev] ORCID iD ORCID: 0009-0008-0057-8239 , Michael Milton [aut, rev, ctb] ORCID iD ORCID: 0000-0002-8965-2595 , Jared Andrews [aut, rev, ctb], Juan Henao [aut, ctb], Edward Yang [aut, ctb], Julie Iskander [rev], Silicon Valley Foundation CZF2019-002443 [fnd], NIH NHGRI 5U24HG004059-18 [fnd], Victoria Cancer Agency ECRF21036 [fnd], NHMRC 1116955 [fnd]

Maintainer: Mengyuan Shen <shen.m at wehi.edu.au>

Citation (from within R, enter citation("cellNexus")):

Installation

To install this package, start R (version "4.6") and enter:


if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

# The following initializes usage of Bioc devel
BiocManager::install(version='devel')

BiocManager::install("cellNexus")

For older versions of R, please refer to the appropriate Bioconductor release.

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("cellNexus")
cellNexus HTML
Gene Expression Explore HTML
Metadata Explore HTML
Reference Manual PDF
NEWS Text

Details

biocViews AssayDomain, Clustering, DifferentialExpression, GeneExpression, Infrastructure, Normalization, QualityControl, RNASeq, Sequencing, ShinyApps, SingleCell, Software, Transcription, Transcriptomics
Version 0.99.23
In Bioconductor since BioC 3.24 (R-4.6)
License GPL-3
Depends R (>= 4.5.0)
Imports dplyr, SummarizedExperiment, SingleCellExperiment, purrr (>= 1.0.0), BiocGenerics, glue, HDF5Array, DBI, tools, httr, curl, cli, SeuratObject, Seurat, methods, rlang, S4Vectors, tibble, utils, dbplyr (>= 2.3.0), duckdb, checkmate, shiny, shinyWidgets, zellkonverter, anndataR, stringr, Matrix, rclipboard
System Requirements Python
URL https://github.com/MangiolaLaboratory/cellNexus https://mangiolalaboratory.github.io/cellNexus/
Bug Reports https://github.com/MangiolaLaboratory/cellNexus/issues
See More
Suggests BiocStyle, knitr, rmarkdown, testthat, basilisk, arrow, reticulate, spelling, forcats, ggplot2, rprojroot, openssl, DelayedArray, tidybulk, BiocParallel, preprocessCore
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Package Archives

Follow Installation instructions to use this package in your R session.

Source Package cellNexus_0.99.23.tar.gz
Windows Binary (x86_64) cellNexus_0.99.23.zip
macOS Binary (big-sur-x86_64) cellNexus_0.99.23.tgz
macOS Binary (sonoma-arm64) cellNexus_0.99.23.tgz
Source Repository git clone https://git.bioconductor.org/packages/cellNexus
Source Repository (Developer Access) git clone git@git.bioconductor.org:packages/cellNexus
Bioc Package Browser https://code.bioconductor.org/browse/cellNexus/
Package Short Url https://bioconductor.org/packages/cellNexus/
Package Downloads Report Download Stats