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Analysis of pooled genetic screens

Bioconductor version: Release (3.19)

Package for the analysis of pooled genetic screens (e.g. CRISPR-KO). The analysis of such screens is based on the comparison of gRNA abundances before and after a cell proliferation phase. The gscreend packages takes gRNA counts as input and allows detection of genes whose knockout decreases or increases cell proliferation.

Author: Katharina Imkeller [cre, aut], Wolfgang Huber [aut]

Maintainer: Katharina Imkeller <k.imkeller at>

Citation (from within R, enter citation("gscreend")):


To install this package, start R (version "4.4") and enter:

if (!require("BiocManager", quietly = TRUE))


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:

Example_simulated HTML R Script
Reference Manual PDF


biocViews CRISPR, PooledScreens, Software, StatisticalMethod
Version 1.18.0
In Bioconductor since BioC 3.10 (R-3.6) (4.5 years)
License GPL-3
Depends R (>= 3.6)
Imports SummarizedExperiment, nloptr, fGarch, methods, BiocParallel, graphics
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Suggests knitr, testthat, rmarkdown, BiocStyle
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Follow Installation instructions to use this package in your R session.

Source Package gscreend_1.18.0.tar.gz
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macOS Binary (x86_64) gscreend_1.18.0.tgz
macOS Binary (arm64) gscreend_1.18.0.tgz
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