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Differential Expression Analysis of NanoString nCounter Data

Bioconductor version: Release (3.19)

This Package utilizes a generalized linear model(GLM) of the negative binomial family to characterize count data and allows for multi-factor design. NanoStrongDiff incorporate size factors, calculated from positive controls and housekeeping controls, and background level, obtained from negative controls, in the model framework so that all the normalization information provided by NanoString nCounter Analyzer is fully utilized.

Author: hong wang < at>, tingting zhai <tingting.zhai at>, chi wang < at>

Maintainer: tingting zhai <tingting.zhai at>,hong wang < at>

Citation (from within R, enter citation("NanoStringDiff")):


To install this package, start R (version "4.4") and enter:

if (!require("BiocManager", quietly = TRUE))


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:

NanoStringDiff Vignette PDF R Script
Reference Manual PDF


biocViews DifferentialExpression, Normalization, Software
Version 1.34.0
In Bioconductor since BioC 3.2 (R-3.2) (9 years)
License GPL
Depends Biobase
Imports matrixStats, methods, Rcpp
System Requirements
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Suggests testthat, BiocStyle
Linking To Rcpp
Depends On Me
Imports Me
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Follow Installation instructions to use this package in your R session.

Source Package NanoStringDiff_1.34.0.tar.gz
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macOS Binary (x86_64) NanoStringDiff_1.34.0.tgz
macOS Binary (arm64) NanoStringDiff_1.34.0.tgz
Source Repository git clone
Source Repository (Developer Access) git clone
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