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IgGeneUsage

This is the released version of IgGeneUsage; for the devel version, see IgGeneUsage.

All versions 3.24 (devel), 3.23 (release), 3.22, 3.21, 3.20, 3.19, 3.18, 3.17, 3.16, 3.15, 3.14, 3.13, 3.12, 3.11, 3.10

Differential gene usage in immune repertoires


Bioconductor version: Release (3.23)

Detection of biases in the usage of immunoglobulin (Ig) genes is an important task in immune repertoire profiling. IgGeneUsage detects aberrant Ig gene usage between biological conditions using a probabilistic model which is analyzed computationally by Bayes inference. With this IgGeneUsage also avoids some common problems related to the current practice of null-hypothesis significance testing.

Author: Simo Kitanovski [aut, cre]

Maintainer: Simo Kitanovski <simo.kitanovski at uni-due.de>

Citation (from within R, enter citation("IgGeneUsage")):

Simo Kitanovski. IgGeneUsage: Differential gene usage in immune repertoires. doi:10.18129/B9.bioc.IgGeneUsage, R package version 1.26.0, https://bioconductor.org/packages/IgGeneUsage.

Generated from the package metadata; it may differ from the package's own citation.

Installation

To install this package, start R (version "4.6") and enter:

if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("IgGeneUsage")

For older versions of R, please refer to the appropriate Bioconductor release.

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("IgGeneUsage")
User Manual: IgGeneUsage HTML R Script
Reference ManualPDF
NEWSText
LICENSEText

Details

biocViews Bayesian, BiomedicalInformatics, DifferentialExpression, Genetics, ImmunoOncology, MathematicalBiology, Regression, Software
Version1.26.0
In Bioconductor sinceBioC 3.10 (R-3.6) (7 years)
License MIT + file LICENSE
Depends R (>= 4.2.0)
Imports methods, reshape2 (>= 1.4.3), Rcpp (>= 0.12.0), RcppParallel (>= 5.0.1), rstan (>= 2.18.1), rstantools (>= 2.2.0), SummarizedExperiment, tidyr
System RequirementsGNU make
URLhttps://github.com/snaketron/IgGeneUsage
Bug Reportshttps://github.com/snaketron/IgGeneUsage/issues
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Suggests BiocStyle, knitr, rmarkdown, testthat (>= 2.1.0), ggplot2, ggforce, ggrepel, patchwork
Linking To BH (>= 1.66.0), Rcpp (>= 0.12.0), RcppEigen (>= 0.3.3.3.0), RcppParallel (>= 5.0.1), rstan (>= 2.18.1), StanHeaders (>= 2.18.0)
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Package Archives

Follow Installation instructions to use this package in your R session.

Source Package IgGeneUsage_1.26.0.tar.gz
Windows Binary (x86_64) IgGeneUsage_1.26.0.zip
macOS Binary (big-sur-x86_64) IgGeneUsage_1.26.0.tgz
macOS Binary (sonoma-arm64) IgGeneUsage_1.26.0.tgz
Source Repositorygit clone https://git.bioconductor.org/packages/IgGeneUsage
Source Repository (Developer Access)git clone git@git.bioconductor.org:packages/IgGeneUsage
Package Short Url https://bioconductor.org/packages/IgGeneUsage/
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