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Infers clonal composition of a tumor

Bioconductor version: Release (3.18)

Clomial fits binomial distributions to counts obtained from Next Gen Sequencing data of multiple samples of the same tumor. The trained parameters can be interpreted to infer the clonal structure of the tumor.

Author: Habil Zare and Alex Hu

Maintainer: Habil Zare <zare at>

Citation (from within R, enter citation("Clomial")):


To install this package, start R (version "4.3") and enter:

if (!require("BiocManager", quietly = TRUE))


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:

A likelihood maximization approach to infer the clonal structure of a cancer using multiple tumor samples PDF R Script
Reference Manual PDF


biocViews Bayesian, Clustering, DNASeq, ExomeSeq, GeneticVariability, Genetics, ImmunoOncology, MultipleComparison, Sequencing, Software, TargetedResequencing
Version 1.38.0
In Bioconductor since BioC 2.14 (R-3.1) (10 years)
License GPL (>= 2)
Depends R (>= 2.10), matrixStats
Imports methods, permute
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Source Package Clomial_1.38.0.tar.gz
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