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methylKit

This is the development version of methylKit; for the stable release version, see methylKit.

All versions 3.24 (devel), 3.23 (release), 3.22, 3.21, 3.20, 3.19, 3.18, 3.17, 3.16, 3.15, 3.14, 3.13, 3.12, 3.11, 3.10, 3.9, 3.8, 3.7, 3.6, 3.5, 3.4

DNA methylation analysis from high-throughput bisulfite sequencing results


Bioconductor version: Development (3.24)

methylKit is an R package for DNA methylation analysis and annotation from high-throughput bisulfite sequencing. The package is designed to deal with sequencing data from RRBS and its variants, but also target-capture methods and whole genome bisulfite sequencing. It also has functions to analyze base-pair resolution 5hmC data from experimental protocols such as oxBS-Seq and TAB-Seq. Methylation calling can be performed directly from Bismark aligned BAM files.

Author: Altuna Akalin [aut, cre], Matthias Kormaksson [aut], Sheng Li [aut], Arsene Wabo [ctb], Adrian Bierling [aut], Alexander Blume [aut], Katarzyna Wreczycka [ctb]

Maintainer: Altuna Akalin <aakalin at gmail.com>, Alexander Blume <alex.gos90 at gmail.com>

Citation (from within R, enter citation("methylKit")):

Altuna Akalin, Matthias Kormaksson, Sheng Li, Adrian Bierling, Alexander Blume. methylKit: DNA methylation analysis from high-throughput bisulfite sequencing results. doi:10.18129/B9.bioc.methylKit, R package version 1.39.0, https://bioconductor.org/packages/methylKit.

Generated from the package metadata; it may differ from the package's own citation.

Installation

To install this package, start R (version "4.6") and enter:

if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

## The following initializes the development version of Bioconductor
BiocManager::install(version = "devel")

BiocManager::install("methylKit")

For older versions of R, please refer to the appropriate Bioconductor release.

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("methylKit")
methylKit: User Guide v`r packageVersion('methylKit')` HTML R Script
Reference ManualPDF
NEWSText

Details

biocViews DNAMethylation, MethylSeq, Sequencing, Software
Version1.39.0
In Bioconductor sinceBioC 3.4 (R-3.3) (10 years)
License Artistic-2.0
Depends R (>= 3.5.0), GenomicRanges (>= 1.18.1), methods
Imports IRanges, data.table (>= 1.9.6), parallel, S4Vectors (>= 0.13.13), Seqinfo, KernSmooth, qvalue, emdbook, Rsamtools, gtools, fastseg, rtracklayer, mclust, mgcv, Rcpp, R.utils, limma, grDevices, graphics, stats, utils
System RequirementsGNU make
URLhttps://github.com/al2na/methylKit
Bug Reportshttps://github.com/al2na/methylKit/issues
See More
Suggests testthat (>= 2.1.0), knitr, rmarkdown, genomation, BiocManager
Linking To Rcpp, Rhtslib (>= 1.13.1)
Enhances
Depends On Me
Imports Me deconvR, methInheritSim, methylInheritance
Suggests Me
Links To Me
Build Report Build Report, r-universe

Package Archives

Follow Installation instructions to use this package in your R session.

Source Package methylKit_1.39.0.tar.gz
Windows Binary (x86_64) methylKit_1.39.0.zip
macOS Binary (big-sur-x86_64) methylKit_1.39.0.tgz
macOS Binary (sonoma-arm64) methylKit_1.39.0.tgz
Source Repositorygit clone https://git.bioconductor.org/packages/methylKit
Source Repository (Developer Access)git clone git@git.bioconductor.org:packages/methylKit
Package Short Url https://bioconductor.org/packages/methylKit/
Package Downloads ReportDownload Stats