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This is the development version of ReactomeGraph4R; for the stable release version, see ReactomeGraph4R.

Interface for the Reactome Graph Database

Bioconductor version: Development (3.20)

Pathways, reactions, and biological entities in Reactome knowledge are systematically represented as an ordered network. Instances are represented as nodes and relationships between instances as edges; they are all stored in the Reactome Graph Database. This package serves as an interface to query the interconnected data from a local Neo4j database, with the aim of minimizing the usage of Neo4j Cypher queries.

Author: Chi-Lam Poon [aut, cre] , Reactome [cph]

Maintainer: Chi-Lam Poon <clpoon807 at>

Citation (from within R, enter citation("ReactomeGraph4R")):


To install this package, start R (version "4.4") and enter:

if (!require("BiocManager", quietly = TRUE))

# The following initializes usage of Bioc devel


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:

Introduction HTML R Script
Reference Manual PDF


biocViews DataImport, GraphAndNetwork, Network, Pathways, Reactome, Software
Version 1.13.0
In Bioconductor since BioC 3.13 (R-4.1) (3 years)
License Apache License (>= 2)
Depends R (>= 4.1)
Imports neo4r, utils, getPass, jsonlite, purrr, magrittr, data.table, rlang, ReactomeContentService4R, doParallel, parallel, foreach
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Suggests knitr, rmarkdown, testthat, stringr, networkD3, visNetwork, wesanderson
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Package Archives

Follow Installation instructions to use this package in your R session.

Source Package ReactomeGraph4R_1.13.0.tar.gz
Windows Binary
macOS Binary (x86_64) ReactomeGraph4R_1.13.0.tgz
macOS Binary (arm64) ReactomeGraph4R_1.13.0.tgz
Source Repository git clone
Source Repository (Developer Access) git clone
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