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Macarron

This is the development version of Macarron; for the stable release version, see Macarron.

All versions 3.24 (devel), 3.23 (release), 3.22, 3.21, 3.20, 3.19, 3.18, 3.17, 3.16, 3.15

Prioritization of potentially bioactive metabolic features from epidemiological and environmental metabolomics datasets


Bioconductor version: Development (3.24)

Macarron is a workflow for the prioritization of potentially bioactive metabolites from metabolomics experiments. Prioritization integrates strengths of evidences of bioactivity such as covariation with a known metabolite, abundance relative to a known metabolite and association with an environmental or phenotypic indicator of bioactivity. Broadly, the workflow consists of stratified clustering of metabolic spectral features which co-vary in abundance in a condition, transfer of functional annotations, estimation of relative abundance and differential abundance analysis to identify associations between features and phenotype/condition.

Author: Amrisha Bhosle [aut], Ludwig Geistlinger [aut], Sagun Maharjan [aut, cre]

Maintainer: Sagun Maharjan <sagunmaharjann at gmail.com>

Citation (from within R, enter citation("Macarron")):

Amrisha Bhosle, Ludwig Geistlinger, Sagun Maharjan. Macarron: Prioritization of potentially bioactive metabolic features from epidemiological and environmental metabolomics datasets. doi:10.18129/B9.bioc.Macarron, R package version 1.17.0, https://bioconductor.org/packages/Macarron.

Generated from the package metadata; it may differ from the package's own citation.

Installation

To install this package, start R (version "4.6") and enter:

if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

## The following initializes the development version of Bioconductor
BiocManager::install(version = "devel")

BiocManager::install("Macarron")

For older versions of R, please refer to the appropriate Bioconductor release.

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("Macarron")
Macarron HTML R Script
Reference ManualPDF
NEWSText
LICENSEText

Details

biocViews Clustering, Coverage, FunctionalPrediction, Metabolomics, Sequencing, Software
Version1.17.0
In Bioconductor sinceBioC 3.15 (R-4.2) (4.5 years)
License MIT + file LICENSE
Depends R (>= 4.5.0), SummarizedExperiment
Imports BiocParallel, DelayedArray, WGCNA, ff, data.table, dynamicTreeCut, Maaslin2, plyr, stats, psych, logging, methods, utils
System Requirements
URLhttp://huttenhower.sph.harvard.edu/macarron
Bug Reportshttps://forum.biobakery.org/c/microbial-community-profiling/macarron
See More
Suggests knitr, BiocStyle, optparse, testthat (>= 2.1.0), rmarkdown, markdown
Linking To
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Depends On Me
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Build Report Build Report, r-universe

Package Archives

Follow Installation instructions to use this package in your R session.

Source Package Macarron_1.17.0.tar.gz
Windows Binary (x86_64) Macarron_1.17.0.zip
macOS Binary (big-sur-x86_64) Macarron_1.17.0.tgz
macOS Binary (sonoma-arm64) Macarron_1.17.0.tgz
Source Repositorygit clone https://git.bioconductor.org/packages/Macarron
Source Repository (Developer Access)git clone git@git.bioconductor.org:packages/Macarron
Package Short Url https://bioconductor.org/packages/Macarron/
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