ISLET
This is the development version of ISLET; for the stable release version, see ISLET.
All Bioconductor versions of ISLET
3.24 (devel), 3.23 (release), 3.22, 3.21, 3.20, 3.19, 3.18, 3.17, 3.16
Individual-Specific ceLl typE referencing Tool
Bioconductor version: 3.24 · Package version: 1.15.0
ISLET is a method to conduct signal deconvolution for general -omics data. It can estimate the individual-specific and cell-type-specific reference panels, when there are multiple samples observed from each subject. It takes the input of the observed mixture data (feature by sample matrix), and the cell type mixture proportions (sample by cell type matrix), and the sample-to-subject information. It can solve for the reference panel on the individual-basis and conduct test to identify cell-type-specific differential expression (csDE) genes. It also improves estimated cell type mixture proportions by integrating personalized reference panels.
Author: Hao Feng [aut, cre] 
, Qian Li [aut], Guanqun Meng [aut]
Maintainer: Hao Feng <hxf155 at case.edu>
Citation
From within R, enter citation("ISLET"):
Hao Feng, Qian Li, Guanqun Meng. ISLET: Individual-Specific ceLl typE referencing Tool. doi:10.18129/B9.bioc.ISLET, R package version 1.15.0, https://bioconductor.org/packages/ISLET.
Generated from the package metadata; it may differ from the package's own citation.
Installation
To install this package, start R (version "4.6") and enter:
if (!require("BiocManager", quietly = TRUE))
install.packages("BiocManager")
## The following initializes the development version of Bioconductor
BiocManager::install(version = "devel")
BiocManager::install("ISLET")For older versions of R, please refer to the appropriate Bioconductor release.
Details
| Version | 1.15.0 |
| License | GPL-2 |
| Last updated | 2026-04-28 |
| In Bioconductor since | BioC 3.16 (R-4.2) (3 years) |
| Downloads rank | 1749 of 2,456 |
| Source branch | devel |
| Build report | Bioconductor build system, r-universe |
| biocViews | DifferentialExpression, DifferentialMethylation, GeneExpression, RNASeq, Sequencing, Software, Transcription, Transcriptomics |
| Package Short Url | https://bioconductor.org/packages/ISLET/ |
Documentation
To view documentation for the version of this package installed in your system, start R and enter:
browseVignettes("ISLET")| Individual-specific and cell-type-specific deconvolution using ISLET | HTML | R Script |
| Reference Manual | ||
| NEWS | Text |
Download
Follow the installation instructions to use this package in your R session.
| Source package | ISLET_1.15.0.tar.gz |
| Windows binary (x86_64) | ISLET_1.15.0.zip |
| macOS binary (arm64) | ISLET_1.15.0.tgz |
| macOS binary (x86_64) | ISLET_1.15.0.tgz |
| Source Repository | git clone https://git.bioconductor.org/packages/ISLET |
| Source Repository (Developer Access) | git clone git@git.bioconductor.org:packages/ISLET |
| Package Downloads Report | Download Stats |
Dependencies
Depends: R (>= 4.2.0), Matrix, parallel, BiocParallel, SummarizedExperiment, BiocGenerics, lme4, nnls
Imports: stats, methods, purrr, abind
Suggests: BiocStyle, knitr, rmarkdown, htmltools, RUnit, dplyr