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GOTHiC

Binomial test for Hi-C data analysis

Bioconductor version: 3.23 · Package version: 1.48.0

This is a Hi-C analysis package using a cumulative binomial test to detect interactions between distal genomic loci that have significantly more reads than expected by chance in Hi-C experiments. It takes mapped paired NGS reads as input and gives back the list of significant interactions for a given bin size in the genome.

Installation

if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("GOTHiC")

Details

MaintainerBorbala Mifsud <b.mifsud@qmul.ac.uk>
AuthorBorbala Mifsud and Robert Sugar
LicenseGPL-3
Downloads rank766
Source branchRELEASE_3_23
biocViewsEpigenetics, HiC, ImmunoOncology, Preprocessing, Sequencing, Software

Documentation

Download

Follow the installation instructions to use this package in your R session.

Source packageGOTHiC_1.48.0.tar.gz
Windows binary (x86_64)GOTHiC_1.48.0.zip
macOS binary (arm64)GOTHiC_1.48.0.tgz
macOS binary (x86_64)GOTHiC_1.48.0.tgz
Dependencies

Depends: R (>= 3.5.0), methods, GenomicRanges, Biostrings, BSgenome, data.table

Imports: BiocGenerics, S4Vectors (>= 0.9.38), IRanges, Rsamtools, ShortRead, rtracklayer, ggplot2, BiocManager, grDevices, utils, stats, Seqinfo

Suggests: HiCDataLymphoblast

Enhances: parallel