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DriverNet

Drivernet: uncovering somatic driver mutations modulating transcriptional networks in cancer


Bioconductor version: Release (3.18)

DriverNet is a package to predict functional important driver genes in cancer by integrating genome data (mutation and copy number variation data) and transcriptome data (gene expression data). The different kinds of data are combined by an influence graph, which is a gene-gene interaction network deduced from pathway data. A greedy algorithm is used to find the possible driver genes, which may mutated in a larger number of patients and these mutations will push the gene expression values of the connected genes to some extreme values.

Author: Ali Bashashati, Reza Haffari, Jiarui Ding, Gavin Ha, Kenneth Liu, Jamie Rosner and Sohrab Shah

Maintainer: Jiarui Ding <jiaruid at cs.ubc.ca>

Citation (from within R, enter citation("DriverNet")):

Installation

To install this package, start R (version "4.3") and enter:


if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("DriverNet")

For older versions of R, please refer to the appropriate Bioconductor release.

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("DriverNet")
An introduction to DriverNet PDF R Script
Reference Manual PDF

Details

biocViews Network, Software
Version 1.42.0
In Bioconductor since BioC 2.12 (R-3.0) (11 years)
License GPL-3
Depends R (>= 2.10), methods
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Package Archives

Follow Installation instructions to use this package in your R session.

Source Package DriverNet_1.42.0.tar.gz
Windows Binary DriverNet_1.42.0.zip
macOS Binary (x86_64) DriverNet_1.42.0.tgz
macOS Binary (arm64) DriverNet_1.42.0.tgz
Source Repository git clone https://git.bioconductor.org/packages/DriverNet
Source Repository (Developer Access) git clone git@git.bioconductor.org:packages/DriverNet
Bioc Package Browser https://code.bioconductor.org/browse/DriverNet/
Package Short Url https://bioconductor.org/packages/DriverNet/
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