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BioTIP: An R package for characterization of Biological Tipping-Point

Bioconductor version: Release (3.19)

Adopting tipping-point theory to transcriptome profiles to unravel disease regulatory trajectory.

Author: Zhezhen Wang, Andrew Goldstein, Yuxi Sun, Biniam Feleke, Qier An, Antonio Feliciano, Xinan Yang

Maintainer: Yuxi (Jennifer) Sun <ysun11 at>, Zhezhen Wang <zhezhen at>, and X Holly Yang <xyang2 at>

Citation (from within R, enter citation("BioTIP")):


To install this package, start R (version "4.4") and enter:

if (!require("BiocManager", quietly = TRUE))


For older versions of R, please refer to the appropriate Bioconductor release.


Reference Manual PDF


biocViews GeneExpression, RNASeq, Sequencing, Software, Transcription
Version 1.18.0
In Bioconductor since BioC 3.10 (R-3.6) (4.5 years)
License GPL-2
Depends R (>= 3.6)
Imports igraph, cluster, psych, stringr, GenomicRanges, MASS, scran
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Suggests knitr, markdown, base, rmarkdown, ggplot2
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Follow Installation instructions to use this package in your R session.

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Windows Binary (64-bit only)
macOS Binary (x86_64) BioTIP_1.18.0.tgz
macOS Binary (arm64) BioTIP_1.18.0.tgz
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Source Repository (Developer Access) git clone
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