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This is the development version of sesame; for the stable release version, see sesame.

SEnsible Step-wise Analysis of DNA MEthylation BeadChips

Bioconductor version: Development (3.20)

Tools For analyzing Illumina Infinium DNA methylation arrays. SeSAMe provides utilities to support analyses of multiple generations of Infinium DNA methylation BeadChips, including preprocessing, quality control, visualization and inference. SeSAMe features accurate detection calling, intelligent inference of ethnicity, sex and advanced quality control routines.

Author: Wanding Zhou [aut, cre] , Wubin Ding [ctb], David Goldberg [ctb], Ethan Moyer [ctb], Bret Barnes [ctb], Timothy Triche [ctb], Hui Shen [aut]

Maintainer: Wanding Zhou <zhouwanding at>

Citation (from within R, enter citation("sesame")):


To install this package, start R (version "4.4") and enter:

if (!require("BiocManager", quietly = TRUE))

# The following initializes usage of Bioc devel


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:

0. Basic Usage HTML R Script
1. Quality Control HTML R Script
2. Non-human Array HTML R Script
3. Modeling HTML R Script
4. Data Inference HTML R Script
5. knowYourCG HTML R Script
Reference Manual PDF


biocViews DNAMethylation, MethylationArray, Preprocessing, QualityControl, Software
Version 1.23.8
In Bioconductor since BioC 3.8 (R-3.5) (5.5 years)
License MIT + file LICENSE
Depends R (>= 4.3.0), sesameData
Imports graphics, BiocParallel, utils, methods, stringr, readr, tibble, MASS, wheatmap (>= 0.2.0), GenomicRanges, IRanges, grid, preprocessCore, S4Vectors, ggplot2, BiocFileCache, GenomeInfoDb, stats, SummarizedExperiment, dplyr, reshape2
System Requirements
Bug Reports
See More
Suggests scales, BiocManager, knitr, DNAcopy, e1071, randomForest, RPMM, rmarkdown, testthat, tidyr, BiocStyle, ggrepel, grDevices, KernSmooth, pals
Linking To
Depends On Me
Imports Me MethReg, CytoMethIC
Suggests Me knowYourCG, RnBeads, TCGAbiolinks, sesameData
Links To Me
Build Report Build Report

Package Archives

Follow Installation instructions to use this package in your R session.

Source Package sesame_1.23.8.tar.gz
Windows Binary
macOS Binary (x86_64) sesame_1.23.8.tgz
macOS Binary (arm64) sesame_1.23.8.tgz
Source Repository git clone
Source Repository (Developer Access) git clone
Bioc Package Browser
Package Short Url
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