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scGraphVerse

This is the development version of scGraphVerse; for the stable release version, see scGraphVerse.

All versions 3.24 (devel), 3.23 (release), 3.22

scGraphVerse: A Gene Network Analysis Package


Bioconductor version: Development (3.24)

A package for inferring, comparing, and visualizing gene networks from single-cell RNA sequencing data. It integrates multiple methods (GENIE3, GRNBoost2, ZILGM, PCzinb, and JRF) for robust network inference, supports consensus building across methods or datasets, and provides tools for evaluating regulatory structure and community similarity. GRNBoost2 requires Python package 'arboreto' which can be installed using init_py(install_missing = TRUE). This package includes adapted functions from ZILGM (Park et al., 2021), JRF (Petralia et al., 2015), and learn2count (Nguyen et al. 2023) packages with proper attribution under GPL-2 license.

Author: Francesco Cecere [aut, cre] ORCID iD ORCID: 0000-0002-0329-0870 , Annamaria Carissimo [aut], Daniela De Canditiis [aut], Claudia Angelini [aut, fnd]

Maintainer: Francesco Cecere <francesco.cecerengs at gmail.com>

Citation (from within R, enter citation("scGraphVerse")):

Francesco Cecere, Annamaria Carissimo, Daniela De Canditiis, Claudia Angelini. scGraphVerse: scGraphVerse: A Gene Network Analysis Package. doi:10.18129/B9.bioc.scGraphVerse, R package version 1.3.0, https://bioconductor.org/packages/scGraphVerse.

Generated from the package metadata; it may differ from the package's own citation.

Installation

To install this package, start R (version "4.6") and enter:

if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

## The following initializes the development version of Bioconductor
BiocManager::install(version = "devel")

BiocManager::install("scGraphVerse")

For older versions of R, please refer to the appropriate Bioconductor release.

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("scGraphVerse")
scGraphVerse Case Study: B-cell GRN Reconstruction HTML R Script
scGraphVerse Simulation Study: Sim & GRN Reconstruction HTML R Script
Reference ManualPDF
NEWSText
LICENSEText

Details

biocViews GeneRegulation, GeneSetEnrichment, GraphAndNetwork, KEGG, Network, NetworkEnrichment, NetworkInference, Pathways, RNASeq, Reactome, Sequencing, SingleCell, Software, Visualization
Version1.3.0
In Bioconductor sinceBioC 3.22 (R-4.5) (1 year)
License GPL-3 + file LICENSE
Depends R (>= 4.5.0)
Imports BiocBaseUtils, BiocParallel (>= 1.30.0), doParallel, doRNG, GENIE3, Matrix, MultiAssayExperiment, SingleCellExperiment, SummarizedExperiment, distributions3, dplyr, grDevices, graphics, httr, igraph, jsonlite, methods, parallel, reticulate, tidyr, glmnet, MASS, utils, stats, S4Vectors, graph, mpath
System RequirementsPython (>= 3.6) and arboreto Python package for GRNBoost2 method. Use init_py(install_missing = TRUE) for automated installation.
URLhttps://ngsFC.github.io/scGraphVerse
Bug Reportshttps://github.com/ngsFC/scGraphVerse/issues
See More
Suggests AnnotationDbi, BiocStyle, clusterProfiler, DOSE, enrichplot, fmsb, ggplot2, ggraph, gridExtra, INetTool, org.Hs.eg.db, org.Mm.eg.db, patchwork, pROC, RColorBrewer, ReactomePA, rentrez, robin, scales, Seurat, STRINGdb, testthat (>= 3.0.0), knitr, rmarkdown, tidyverse, magick, celldex, SingleR, TENxPBMCData, scater, GenomeInfoDb, GenomicRanges
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Package Archives

Follow Installation instructions to use this package in your R session.

Source Package scGraphVerse_1.3.0.tar.gz
Windows Binary (x86_64)
macOS Binary (big-sur-x86_64) scGraphVerse_1.3.0.tgz
macOS Binary (sonoma-arm64) scGraphVerse_1.3.0.tgz
Source Repositorygit clone https://git.bioconductor.org/packages/scGraphVerse
Source Repository (Developer Access)git clone git@git.bioconductor.org:packages/scGraphVerse
Package Short Url https://bioconductor.org/packages/scGraphVerse/
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