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PscanR

This is the development version of PscanR; to use it, please install the devel version of Bioconductor.

Motif Enrichment Analysis of Regulatory DNA Sequences


Bioconductor version: Development (3.24)

R implementation of the 'Pscan' algorithm for motif enrichment analysis in regulatory DNA sequences, based on Zambelli et al. (2009) <doi:10.1093/nar/gkp464>. 'PscanR' scans a set of DNA sequences (e.g., promoters) from co-regulated or co-expressed genes, using transcription factor binding motifs from databases such as JASPAR. It identifies significantly enriched motifs, providing thus hints on which transcription factors could be common regulators of the genes studied, together with the location of their candidate binding sites in the sequences.

Author: Federico Zambelli [aut, cre] ORCID iD ORCID: 0000-0003-3487-4331 , Giulio Pavesi [aut] ORCID iD ORCID: 0000-0001-5705-6249 , Diana Betelli [ctb], Italy's National Recovery and Resilience Plan (PNRR) [fnd] (project ELIXIRNextGenIT, R0000010)

Maintainer: Federico Zambelli <federico.zambelli at unimi.it>

Citation (from within R, enter citation("PscanR")):

Federico Zambelli, Giulio Pavesi. PscanR: Motif Enrichment Analysis of Regulatory DNA Sequences. doi:10.18129/B9.bioc.PscanR, R package version 0.99.3, https://bioconductor.org/packages/PscanR.

Generated from the package metadata; it may differ from the package's own citation.

Installation

To install this package, start R (version "4.6") and enter:

if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

## The following initializes the development version of Bioconductor
BiocManager::install(version = "devel")

BiocManager::install("PscanR")

For older versions of R, please refer to the appropriate Bioconductor release.

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("PscanR")
Building a background for PscanR HTML
Motif enrichment analysis with PscanR: Arabidopsis BPC target promoters HTML
Motif enrichment analysis with PscanR: mouse retinal promoters HTML
PscanR Concepts and Input Preparation HTML
PscanR Quick Overview HTML
Reference ManualPDF
NEWSText

Details

biocViews GeneRegulation, MotifAnnotation, SequenceMatching, Software, Transcription
Version0.99.3
In Bioconductor sinceBioC 3.24 (R-4.6)
License GPL-3
Depends R (>= 4.5.0)
Imports BiocFileCache, BiocParallel, BiocGenerics, Biostrings, ExperimentHub, ggplot2, grDevices, methods, pheatmap, RSQLite, stats, TFBSTools, UCSC.utils, utils
System Requirements
URLhttps://github.com/Federico77z/PscanR
Bug Reportshttps://github.com/Federico77z/PscanR/issues
See More
Suggests AnnotationDbi, BiocStyle, BSgenome, BSgenome.Athaliana.TAIR.TAIR9, BSgenome.Hsapiens.UCSC.hg38, BSgenome.Mmusculus.UCSC.mm10, BSgenome.Scerevisiae.UCSC.sacCer3, GenomicFeatures, GenomicRanges, GenomeInfoDb, IRanges, JASPAR2020, JASPAR2022, JASPAR2024, knitr, org.Hs.eg.db, org.Mm.eg.db, org.Sc.sgd.db, PscanRBackgrounds, rmarkdown, testthat, TxDb.Scerevisiae.UCSC.sacCer3.sgdGene, txdbmaker
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Package Archives

Follow Installation instructions to use this package in your R session.

Source Package
Windows Binary (x86_64)
macOS Binary (big-sur-x86_64)
macOS Binary (sonoma-arm64)
Source Repositorygit clone https://git.bioconductor.org/packages/PscanR
Source Repository (Developer Access)git clone git@git.bioconductor.org:packages/PscanR
Package Short Url https://bioconductor.org/packages/PscanR/
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