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CellTrails

This is the development version of CellTrails; for the stable release version, see CellTrails.

All versions 3.24 (devel), 3.23 (release), 3.22, 3.21, 3.20, 3.19, 3.18, 3.17, 3.16, 3.15, 3.14, 3.13, 3.12, 3.11, 3.10, 3.9, 3.8

Reconstruction, visualization and analysis of branching trajectories


Bioconductor version: Development (3.24)

CellTrails is an unsupervised algorithm for the de novo chronological ordering, visualization and analysis of single-cell expression data. CellTrails makes use of a geometrically motivated concept of lower-dimensional manifold learning, which exhibits a multitude of virtues that counteract intrinsic noise of single cell data caused by drop-outs, technical variance, and redundancy of predictive variables. CellTrails enables the reconstruction of branching trajectories and provides an intuitive graphical representation of expression patterns along all branches simultaneously. It allows the user to define and infer the expression dynamics of individual and multiple pathways towards distinct phenotypes.

Author: Daniel Ellwanger [aut, cre, cph]

Maintainer: Daniel Ellwanger <dc.ellwanger.dev at gmail.com>

Citation (from within R, enter citation("CellTrails")):

Daniel Ellwanger. CellTrails: Reconstruction, visualization and analysis of branching trajectories. doi:10.18129/B9.bioc.CellTrails, R package version 1.31.0, https://bioconductor.org/packages/CellTrails.

Generated from the package metadata; it may differ from the package's own citation.

Installation

To install this package, start R (version "4.6") and enter:

if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

## The following initializes the development version of Bioconductor
BiocManager::install(version = "devel")

BiocManager::install("CellTrails")

For older versions of R, please refer to the appropriate Bioconductor release.

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("CellTrails")
CellTrails: Reconstruction, visualization, and analysis of branching trajectories from single-cell expression data PDF R Script
Reference ManualPDF
NEWSText

Details

biocViews Clustering, DataRepresentation, DifferentialExpression, DimensionReduction, GeneExpression, ImmunoOncology, Sequencing, SingleCell, Software, TimeCourse
Version1.31.0
In Bioconductor sinceBioC 3.8 (R-3.5) (8 years)
License Artistic-2.0
Depends R (>= 3.5), SingleCellExperiment
Imports BiocGenerics, Biobase, cba, dendextend, dtw, EnvStats, ggplot2, ggrepel, grDevices, igraph, maptree, methods, mgcv, reshape2, Rtsne, stats, splines, SummarizedExperiment, utils
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Suggests AnnotationDbi, destiny, RUnit, scater, scran, knitr, org.Mm.eg.db, rmarkdown
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Package Archives

Follow Installation instructions to use this package in your R session.

Source Package CellTrails_1.31.0.tar.gz
Windows Binary (x86_64) CellTrails_1.31.0.zip
macOS Binary (big-sur-x86_64) CellTrails_1.31.0.tgz
macOS Binary (sonoma-arm64) CellTrails_1.31.0.tgz
Source Repositorygit clone https://git.bioconductor.org/packages/CellTrails
Source Repository (Developer Access)git clone git@git.bioconductor.org:packages/CellTrails
Package Short Url https://bioconductor.org/packages/CellTrails/
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