VarCon

This is the development version of VarCon; for the stable release version, see VarCon.

VarCon: an R package for retrieving neighboring nucleotides of an SNV


Bioconductor version: Development (3.20)

VarCon is an R package which converts the positional information from the annotation of an single nucleotide variation (SNV) (either referring to the coding sequence or the reference genomic sequence). It retrieves the genomic reference sequence around the position of the single nucleotide variation. To asses, whether the SNV could potentially influence binding of splicing regulatory proteins VarCon calcualtes the HEXplorer score as an estimation. Besides, VarCon additionally reports splice site strengths of splice sites within the retrieved genomic sequence and any changes due to the SNV.

Author: Johannes Ptok [aut, cre]

Maintainer: Johannes Ptok <Johannes.Ptok at posteo.de>

Citation (from within R, enter citation("VarCon")):

Installation

To install this package, start R (version "4.4") and enter:


if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

# The following initializes usage of Bioc devel
BiocManager::install(version='devel')

BiocManager::install("VarCon")

For older versions of R, please refer to the appropriate Bioconductor release.

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("VarCon")
Analysing SNVs with VarCon HTML R Script
Reference Manual PDF
NEWS Text
LICENSE Text

Details

biocViews AlternativeSplicing, FunctionalGenomics, Software
Version 1.13.0
In Bioconductor since BioC 3.13 (R-4.1) (3.5 years)
License GPL-3
Depends Biostrings, BSgenome, GenomicRanges, R (>= 4.1)
Imports methods, stats, IRanges, shiny, shinycssloaders, shinyFiles, ggplot2
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Suggests testthat, knitr, rmarkdown
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Package Archives

Follow Installation instructions to use this package in your R session.

Source Package VarCon_1.13.0.tar.gz
Windows Binary VarCon_1.13.0.zip
macOS Binary (x86_64) VarCon_1.13.0.tgz
macOS Binary (arm64) VarCon_1.13.0.tgz
Source Repository git clone https://git.bioconductor.org/packages/VarCon
Source Repository (Developer Access) git clone git@git.bioconductor.org:packages/VarCon
Bioc Package Browser https://code.bioconductor.org/browse/VarCon/
Package Short Url https://bioconductor.org/packages/VarCon/
Package Downloads Report Download Stats