0.1 Overview

LACE is an algorithmic framework that processes single-cell somatic mutation profiles from cancer samples collected at different time points and in distinct experimental settings, to produce longitudinal models of cancer evolution. The approach solves a Boolean Matrix Factorization problem with phylogenetic constraints, by maximizing a weighted likelihood function computed on multiple time points.

0.2 Installing LACE

The R version of LACE can be installed from BioConductor. To do so, we need to install the R packages LACE depends on and the devtools package.

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0.3 Debug

Please feel free to contact us if you have problems running our tool at or .