Changes in version 1.00.0 (2023-09-14) + imply implemented. Changes in version 0.99.6 + Real data example added. + Unit test modified. o Unit test added previously Changes in version 0.99.4 + Unit test added. + Coding modified in compliance with BioC requirement. Changes in version 0.99.3 + Slope test implemented. + Added a news file to track changes to the package. Changes in version 0.99.2 + Slope test implemented. + Added a news file to track changes to the package.