Changes in version 1.1.0 (2019-04-05) + Submitted package to Bioconductor. Changes in version 1.1.1 (2019-05-03) + Added log2_ratio normalization option. + Fix a bug that prevented strand_specific and stitch mode to work together. Changes in version 1.1.2 (2019-05-09) + rnaseq mode now sets strand_specific to TRUE by default. Changes in version 1.1.3 (2019-05-13) + When parameter validation fails, the metagene2 object will now fall back to the previous set of parameters, instead of ending up in an invalid state. Changes in version 1.1.4 (2019-07-12) + Improved documentation of control samples in design. Changes in version 1.3.1 (2019-11-05) + Added the metagene2_heatmap function, which generates heatmap representation of the binned coverages underlying the metagene2 object. Changes in version 1.3.3 (2019-11-13) + Fixed a bug which caused overlapping contiguous regions to be assigned the wrong coverage values. Changes in version 1.7.2 (2020-12-17) + Removed support for NCIS normalization, which relied on a now deprecated package.