Changes in version 1.6.0 o MPI for parallel computing is avaliable under R 4.0.0 for linux and Mac OS platforms. o Gene expression data of normal tissues (Lung, Prostate and Thyroid) from the GTEx study are included. o Rename DeMixT_S1 function to DeMixT_DE. Changes in version 1.4.0 o Disabled OpenMP under R 4.0.0 for Mac OS platform. Changes in version 1.2.5 o Added pi01 and pi02 as input values for users to initialize the proportion estimation. o Added nspikein as an input value in the DeMixT, DeMixT_S1 and DeMixT_GS functions to specify how many spike-in normal reference samples need to be generated; Setting nspikein at null as a default value, the number of spike-in normal reference samples equal the min(200, 0.3 x My), where My is the number of mixed samples; By setting nspikein equals 0, no spike-in normal reference will be generated; If the input value of data.N2 is not null, nspikein will be forced to be 0. o Added DeMixT_GS function, new proposed gene selection method which applies profile likelihood, for proportion estimation. o Added simulate_2comp function for users to simulate test data for 2-component de-convolution. o Added simulate_3comp function for users to simulate test data for 3-component de-convolution. o Added row names and column names for all output values. o Added gene.selection.method as an input value for DeMixT function. The default is 'GS'. o Added ngene.Profile.selected as an input value for DeMixT function. The default is NA. Changes in version 0.99.0 o New package DeMixT, for cell type-specific deconvolution of heterogeneous tumor samples with two or three components using expression data from RNAseq or microarray platforms