Changes in version 1.3 - Take into account edge weights in clustering algorithms and centrality measure calculations. - Add calculation of the DYNAMO perturbation pattern from signed weight directed networks proposed in Santolini,M. and Barabasi,A.-L. (2018) PNAS 169, 201720589 - Decoupled from synaptome.db and synaptome.data packages. All code, related to graph building from the synaptome.db data is moved to synaptome.db package. Changes in version 1.2.1 - Allow analysis of directed graphs and add four new centrality measures specific for the directed graphs. - Modify annotation functions to allow annotate nodes not only by its name propety but by any other arbitrary property if its value uniquely identify the node. - Added new framework for the visualisation and analysis of enrichment results. Changes in version 0.99.001 - Added a NEWS.md file to track changes to the package.